Prevention of Coronary Artery Disease and Lipid Lowering
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Prevention of Coronary Artery Disease and Lipid Lowering |
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Inflammation CETP LDL Lowering HDL Raising Other Lipid Lowering Obesity Smoking Cessation Vitamins |
| Summary Slides |
ATP 3: Adult Treatment Panel III
-Implications of Recent Clinical Trials for the National Cholesterol Education Program ATP III Guidelines by Dr. Scott M. Grundy
CHAMP: Cardiac Hospitalization Atherosclerosis Management Program
-Rationale and Design by Dr. Gregg C. Fonarow and Dr. Anna Gawlinski (2000)
Cholesterol Metabolism
EPIC-Norfolk: European Prospective Investigation of Cancer
-Value of Lipoprotein Particle Number and Size as Predictors of Coronary Artery Disease in Apparently Healthy Men and Women by Dr. Karim El Harchaoui (2007)
FIT HEART: A Novel Family-based Intervention Trial to Improve Heart Health
-Trial Results by Dr. Lori Mosca
HDL: High Density Lipoprotein
-Overview by Dr. Peter Libby
HDL or LDL
-Which is More Important? by Dr. Christopher P. Cannon (2000)
HMG Reductase Inhibitors
-Meta-analysis of the Impact of HMG Reductase Inhibitors on Clinical Events
Lipid Management Advances
PIOSTAT: Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High Cardiovascular Risk Patients With Elevated High Sensitivity C-Reactive Protein
-Trial Overview by Dr. Markolf Hanefeld (2007)
RESPONSE: Randomized Evaluation of Secondary Prevention by Outpatient Nurse Specialists
-Trial Results by Dr. Ron JG Peters (ESC 2010)
Statin Therapy
-The Benefit of Statin Therapy Before and After Coronary Revascularization by Dr. C. Michael Gibson
| Inflammation |
ARISE: Aggressive Reduction of Inflammation Stops Events
-Study Overview by Dr. Jean-Claude Tardif (ACC 2007)
MEDAL Program: Multinational Etoricoxib and Diclofenac Arthritis Long-term
-Cardiovascular Risk with COX-IIs - MEDAL Program by Dr. Christopher P. Cannon
| CETP |
Dal-OUTCOMES: Effects of the Cholesteryl Ester Transfer Protein Inhibitor Dalcetrapib in Patients with Recent Acute Coronary Syndrome
-Trial Overview by Dr. Gregory G. Schwartz (AHA 2012)
DEFINE: Determining the Efficacy of Tolerability of CETP Inhibition With Anacetrapib
-Trial Results by Dr. Christopher Cannon (AHA 2010)
ILLUSTRATE: Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation
-Trial Overview by Dr. Steven E. Nissen (ACC 2007)
Lipid-Modulating Effects of Evacetrapib, a Novel CETP Inhibitor, Administered as Monotherapy or in Combination with the Most Commonly Used Statins:
-Trial Overview by Dr. Stephen Nicholls (AHA 2011)
| LDL Lowering |
4S: Scandinavian Simvastatin Survival Study
-Diabetes by Dr. SM Haffner
-Elderly and Women by Dr. Tatu A. Miettinen
-Simvastatin vs Placebo for Mortality in Coronary Heart Disease
-Stroke by Dr. Terje R. Pedersen
A to Z: Aggrastat to Zocor
-Aggrastat-Phase of the A to Z Trial (ACC 2003)
ACTIVATE: Acyl-coenzyme A: Cholesterol Acyltransferase (ACAT) Inhibition on the Progression of Coronary Atherosclerosis
-Trial Overview by Dr. Steven E. Nissen (AHA 2005)
AFCAPS/TexCAPS: Air Force Texas Coronary Atherosclerosis Prevention Study
-Results of AFCAPS/TexCAPS by Dr. John R. Downs, et al.
ALLHAT - LLT: Lipid Lowering Substudy Trial of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
ARBITER-2: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 2 Trial
-Trial Overview by Dr. A. Taylor (AHA 2004)
ARMYDA-ACS: Atorvastatin for Reduction of Myocardial Damage During Angioplasty — Acute Coronary Syndromes
-Trial Overview by Dr. Germano Di Sciascio
ASTEROID: A Study To Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden
-Trial Overview by Dr. Steven E. Nissen (ACC 2006)
AVERT: Atorvastatin Versus Revascularization Treatments
-Trial Overview by Dr. Bertram Pitt (AHA 1998)
CARE: Cholesterol And Recurrent Events
-The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels by Dr. Frank M. Sacks, et al.
GAUSS: Goal Achievement after Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects
-Interim Results by Dr. Evan Stein et al. (AHA 2012)
IDEAL: Incremental Decrease in Clinical Endpoints Through Aggressive Lipid Lowering
-Trial Overview by Dr. Terje Pedersen (AHA 2005)
JUPITER: Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin
-Trial Overview by Dr. Paul Ridker (AHA 2008)
LAPLACE-TIMI57
-LDL-C Assessment with PCSK9 monoclonaL Antibody inhibition Combined with statin thErapy – Thrombolysis In Myocardial Infarction-57 by Dr. Robert P. Giugliano (AHA 2012)
LIPID: Long-Term Intervention With Pravastatin in Ischemic Disease Trial
Lipid Management
-How Aggressive Do We Get on Lipids? by Dr. Christopher P. Cannon
Long-Term Reduction in Low-Density Lipoprotein Cholesterol: A Mendelian Randomized Controlled Trial of Long-Term Reduction of LDL-C Beginning Early in Life
-Trial Overview by Dr. Brian A. Ference (ACC 2012)
MEGA: Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese
-Trial Overview by Dr. Haruo Nakamura (AHA 2005)
METEOR: Measuring Effects of Intima-Media Thickness: An Evaluation of Rosuvastatin
-Trial Overview by Dr. John R. Crouse III (ACC 2007)
-View an Animated Presentation
PCSK9: A Randomized, Double Blind, Placebo-controlled Trial of the Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease in Patients with Primary Hypercholesterolemia
-Trial Overview by Dr. James McKenney (ACC 2012)
SHARP: Study of Heart and Renal Protection
-Trial Results by Dr. Colin Baigent and Dr. Martin Landray
PROVE IT - TIMI 22: Pravastatin Or Atorvastatin Evaluation and Infection Therapy - Thrombolysis In Myocardial Infarction 22
-Trial Overview by Dr. Christopher Cannon
RAAVE: Rosuvastatin Affecting Aortic Valve Endothelium to Slow the Progressions of Aortic Stenosis
-Trial Overview by Dr. Luis M. Moura (2007)
REVERSAL: Reversing Atherosclerosis with Aggressive Lipid Lowering
-Trial Overview by Dr. Steven E. Nissen (AHA 2003)
RUTHERFORD: Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder
-Interim Results by Dr. Frederick J. Raal (AHA 2012)
SAGE: Study Assessing Goals in the Elderly
-Trial Overview by Dr. Prakash Deedwania (2007)
SATURN: Comparison of the Progression of Coronary Atherosclerosis for Two High-efficacy Statin Regimens with Different HDL Effects
-Trial Overview by Dr. Stephen Nicholls (AHA 2011)
Simvastatin
-Lipid-Altering Efficacy and Safety of Simvastatin 80 mg/day: Long-Term Experience in a Large Group of Patients with Hypercholesterolemia by Dr. Leiv Ose, et al.
Statin Therapy
-The Benefit of Statin Therapy Before and After Coronary Revascularization by Dr. C. Michael Gibson
TNT: Treating to New Targets
-Trial Overview by Dr. John C. LaRosa (ACC 2005)
WOSCOPS: West Of Scotland Coronary Prevention Study
-Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia by Dr. James Shepherd
YELLOW: Reduction in Yellow Plaque by Aggressive Lipid Lowering Therapy
-Trial Overview by Dr. Annapoorna Kini (ACC 2012)
| HDL Raising |
ASSERT: First Major Clinical Trial of an Oral Agent Inducing Apo-A-I Synthesis: A New Approach to Raising HDL and CV Risk Modification
-Trial Results by Dr. Stephen Nicholls (AHA 2010)
Atherosclerosis
-Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis by Dr. Stephen J. Nicholls, et al. (2007)
Dal-OUTCOMES: Effects of the Cholesteryl Ester Transfer Protein Inhibitor Dalcetrapib in Patients with Recent Acute Coronary Syndrome
-Trial Overview by Dr. Gregory G. Schwartz (AHA 2012)
ERASE: Effect of rHDL on Atherosclerosis-Safety and Efficacy
-Trial Overview by Dr. Jean-Claude Tardif (ACC 2007)
ILLUSTRATE: Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation
-Trial Overview by Dr. Steven E. Nissen (ACC 2007)
SATURN: Comparison of the Progression of Coronary Atherosclerosis for Two High-efficacy Statin Regimens with Different HDL Effects
-Trial Overview by Dr. Stephen Nicholls (AHA 2011)
Simvastatin's Impact on HDL
-Effects of High Doses of Simvastatin and Atorvastatin on High-Density Lipoprotein Cholesterol and Apolipoprotein A-1 by Dr. John R. Crouse III, et al. (1999)
-Simvastatin Increases HDL-C and Apolipoprotein A-1 Levels Significantly More Than Atorvastatin by Dr. John P. Kastelein et al. (ACC 2000)
VA-HIT: Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial
| Other Lipid Lowering |
ACTIVATE: Acyl-coenzyme A: Cholesterol Acyltransferase (ACAT) Inhibition on the Progression of Coronary Atherosclerosis
-Simvastatin vs Placebo for Mortality in Coronary Heart Disease by Dr. Steven E. Nissen (AHA 2005)
BIP: Bezafibrate Infarction Prevention
-Trial Results (European Society of Cardiology Meeting, 1998)
OmniHeart Feeding Study
-DASH Diet vs DASH with Higher Protein Content by Dr. Lawrence J. Appel (AHA 2005)
SEARCH: Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
-Trial Overview by Dr. Rory Collins and Dr. Jane Armitage (AHA 2008)
Vytorin
-Postmarket Statin Analysis of Vytorin and Cancer by Dr. Alawi A. Alsheikh-Ali and Dr. Richard H. Karas
| Obesity |
RIO EUROPE: A Randomised Double-Blind Study of Weight Reducing Effect and Safety of Rimonabant in Obese Patients With or Without Comorbidities
-Trial Overview by Dr. Luc Van Gaal (ACC 2005)
RIO LIPIDS: Rimonabant in Obesity
-Trial Overview by Dr. Jean-Pierre Despres (ACC 2004)
| Smoking Cessation |
STRATUS-US: Smoking Cessation in Smokers Motivated to Quit
-Trial Overview by Dr. Robert Anthenelli (ACC 2004)
| Vitamins |
NORVIT: Norwegian Vitamin Trial
-Trial Overview by Dr. Kaare Harold Bønaa (European Society of Cardiology Congress 2005)
Physicians' Health Study II: Multivitamins in the Prevention of Cardiovascular Disease in Men
-Trial Overview by Dr. Howard D. Sesso et al. (AHA 2012)
WENBIT Trial: Western Norway B-vitamin Intervention Trial
-Trial Overview by Dr. Marta Ebbing (European Society of Cardiology Congress 2007)
Women's Health Study
-Vitamine E in Primary Prevention by Dr. Julie E. Buring (ACC 2005)
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