Clinical Trial Results Home

Anticoagulation

 Contents
Pathophysiology
Factor XA Inhibition
Factor IX Inhibition
Warfarin
 Pathophysiology

Heparin-Induced Thrombocytopenia

      -Heparin as a Cause of Thrombosis and "The HIT Syndromes" by Dr. Amjad AlMahameed

Hypercoaguable States

      -What Every Clinician Needs to Know by Dr. Amjad AlMahameed

Pathways in Anticoagulation: What's Most Efficacious, Safest

      -Overview by Dr. Richard C. Becker (AHA 2010)

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 Factor XA Inhibition

FUTURA OASIS 8: Low vs. Standard Dose Unfractionated Heparin for PCI in ACS Patients Treated with Fondaparinux

      -Trial Results by Dr. Sanjit Jolly (ESC 2010)

 

New Approaches to Chronic Anticoagulation: Factor XA Inhibition

      -Meeting the Unmet Needs in Chronic Anticoagulation by Dr. C. Michael Gibson (ACC 2007)

XA Inhibitors

      -Are They All the Same? by Dr. Alexander G. G. Turpie

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 Factor IX Inhibition

Aptamer Technology Overview:

      -Factor IXa Inhibition Aptamer Technology Overview and First Results with RB006/RB007 by Dr. Mauricio G. Cohen (TCT 2009)

 

RADAR: A Randomized, Partially-Blinded, Multi-Center, Active-Controlled, Dose-Ranging Study Assessing the Safety, Efficacy, and Pharmacodynamics of the REG1 Anticoagulation System Compared to Unfractionated Heparin or Low Molecular Weight Heparin in Subjects with Acute Coronary Syndromes

      -Primary Results by Dr. Tom Povsic (ACC 2011)

 

A Prospective RADAR Pharamacokinetic and Pharmacodynamic Substudy: Pegnivacogin (RB006), a Direct Factor IXa Inhibitor, Results in Consistent and Near Complete Inhibition of Factor IX Activity in Patients with Acute Coronary Syndromes

      -Study Overview by Dr. Thomas Povsic (AHA 2010)

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 Warfarin

ARISTOTLE: Apixaban versus Warfarin in Patients with Atrial Fibrillation

      -Trial Results by Dr. Christopher Granger and Dr. Lars Wallentin (ESC 2011)

      -Efficacy and Safety by Dr. Christopher Granger and Dr. Lars Wallentin (ESC 2011)

 

ARISTOTLE Sub-analysis in Japanese patients: Apixaban versus Warfarin in Patients with Atrial Fibrillation

      -Study Overview by Dr. Shinya Goto (ACC 2012)

 

ARISTOTLE CHADS Subgroup Study: Efficacy and Safety of Apixaban Compared with Warfarin According to Patient Risk of Stroke and Bleeding in Atrial Fibrillation

      -Study Overview by Dr. Renato Lopes (ACC 2012) 

 

GRACE Registry: Global Registry of Acute Coronary Events

      -Combining Warfarin and Antiplatelet Therapy After Coronary Stenting: Is It Safe and Effective to Use Just One Antiplatelet Agent? by Dr. Michael C. Nguyen

 

PROTECT AF: Percutaneous Closure of the Left Atrial Appendage versus Warfarin Therapy for Prevention of Stroke in Patients with Atrial Fibrillation: A Randomized Non-Inferiority Trial

      -Trial Overview by Dr. David R. Holmes (AHA 2002)

RELY: Randomized Evaluation of Long-term anticoagulant therapY

      -Dabigatran Compared to Warfarin in 18,113 Patients with Atrial Fibrillation at Risk of Stroke

      -Efficacy and Safety of Dabigatran vs. Warfarin in Patients with Atrial Fibrillation: Japanese Population by Dr. Shinya Goto

 

RELY CHADS-VASC2 Subgroup: Randomized Evaluation of Long-term anticoagulant therapY

      -Insights to RELY Subgroup Analysis by Dr. Hisao Ogawa

 

ROCKET-AF: Stroke Prevention Using the Oral Direct Factor Xa Inhibitor Rivaroxaban Compared with Warfarin in Patients with Nonvalvular Atrial Fibrillation

   -Trial Overview by Dr. Kenneth Mahaffey and Dr. Keith Fox (AHA 2010)

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